H2N2V1, France, Analysis, bibRecord, 000002

Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study

Identifieur interne : 000002 ( France/Analysis ); précédent : 000001; suivant : 000003

Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study

Auteurs : Sylvie Behillil [France] ; Faten May [France] ; Slim Fourati [France] ; Charles-Edouard Luyt [France] ; Thomas Chicheportiche [France] ; Romain Sonneville [France] ; Yacine Tandjaoui-Lambiotte [France] ; Damien Roux [France] ; Laurent Guérin [France] ; Julien Mayaux [France] ; Eric Maury [France] ; Alexis Ferré [France] ; Jean-François Georger [France] ; Guillaume Voiriot [France] ; Vincent Enouf [France] ; Sylvie Van Der Werf [France] ; Armand Mekontso Dessap [France] ; Nicolas De Prost [France]

Source :

Clinical Infectious Diseases [ 1058-4838 ] ; 2019-09-20.

RBID : Hal:hal-02383473

Descripteurs français

Wicri :
- topic : Adulte.

English descriptors

mix :
- Adult, H1N1 Subtype, Influenza A Virus, Oseltamivir, Pneumonia, Respiratory Distress Syndrome, Viral.

Abstract

In a multicenter cohort study including 22 oseltamivir-treated patients with influenza A(H1N1)pdm09 acute respiratory distress syndrome, prevalence of the H275Y substitution in the neuraminidase, responsible for highly reduced sensitivity to oseltamivir, was 23%. Patients infected with the H275Y mutant virus had higher day-28 mortality than others (80% vs 12%; p=0.011).

Url:

https://hal.sorbonne-universite.fr/hal-02383473

DOI: 10.1093/cid/ciz904

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000227
to stream Hal, to step Curation: 000227
to stream Hal, to step Checkpoint: 000008
to stream Main, to step Merge: 000025
to stream Main, to step Curation: 000025
to stream Main, to step Exploration: 000025
to stream France, to step Extraction: 000002

Links to Exploration step

Hal:hal-02383473

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study</title>
<author><name sortKey="Behillil, Sylvie" sort="Behillil, Sylvie" uniqKey="Behillil S" first="Sylvie" last="Behillil">Sylvie Behillil</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-525918" status="OLD">          <idno type="RNSR">200818198A</idno>
          <orgName>Génétique moléculaire des virus à ARN</orgName>
          <orgName type="acronym">(U-Pasteur_ 2 / UMR_3569)</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Institut Pasteur25-28 rue du Docteur ROUX75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr/fr/sante-publique/centres-nationaux-reference/cnr/virus-infections-respiratoires-dont-grippe</ref>
          </desc>
          <listRelation>            <relation active="#struct-300027" type="direct"></relation>
            <relation name="U-Pasteur_ 2" active="#struct-300301" type="direct"></relation>
            <relation name="UMR_3569" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID">          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <date type="start">1887-06-04</date>
          <desc>            <address>              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U-Pasteur_ 2" active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD">          <idno type="ISNI">0000000121514068</idno>
          <idno type="IdRef">027542084</idno>
          <orgName>Université Paris Diderot - Paris 7</orgName>
          <orgName type="acronym">UPD7</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-paris-diderot.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR_3569" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="May, Faten" sort="May, Faten" uniqKey="May F" first="Faten" last="May">Faten May</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-103061" status="VALID">          <orgName>Groupe Henri Mondor-Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-300087" type="direct"></relation>
            <relation active="#struct-300088" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300087" type="direct"><org type="institution" xml:id="struct-300087" status="VALID">          <orgName>Hôpital Henri Mondor</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300088" type="direct"><org type="institution" xml:id="struct-300088" status="VALID">          <orgName>Hôpital Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Fourati, Slim" sort="Fourati, Slim" uniqKey="Fourati S" first="Slim" last="Fourati">Slim Fourati</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-103061" status="VALID">          <orgName>Groupe Henri Mondor-Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-300087" type="direct"></relation>
            <relation active="#struct-300088" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300087" type="direct"><org type="institution" xml:id="struct-300087" status="VALID">          <orgName>Hôpital Henri Mondor</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300088" type="direct"><org type="institution" xml:id="struct-300088" status="VALID">          <orgName>Hôpital Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Luyt, Charles Edouard" sort="Luyt, Charles Edouard" uniqKey="Luyt C" first="Charles-Edouard" last="Luyt">Charles-Edouard Luyt</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-353778" status="VALID">          <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
          <desc>            <address>              <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
          </desc>
        </hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Chicheportiche, Thomas" sort="Chicheportiche, Thomas" uniqKey="Chicheportiche T" first="Thomas" last="Chicheportiche">Thomas Chicheportiche</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-353778" status="VALID">          <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
          <desc>            <address>              <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
          </desc>
        </hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Sonneville, Romain" sort="Sonneville, Romain" uniqKey="Sonneville R" first="Romain" last="Sonneville">Romain Sonneville</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2607" status="VALID">          <orgName>CIC - CHU Bichat</orgName>
          <desc>            <address>              <addrLine>Gh Xavier Bichat - Claude Bernard PARIS VII 46, Rue Henri Huchard 75018 PARIS</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="CIC7" active="#struct-303623" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="CIC7" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Tandjaoui Lambiotte, Yacine" sort="Tandjaoui Lambiotte, Yacine" uniqKey="Tandjaoui Lambiotte Y" first="Yacine" last="Tandjaoui-Lambiotte">Yacine Tandjaoui-Lambiotte</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-85018" status="OLD">          <orgName>Service de Réanimation Médico-Chirurgicale [Avicenne]</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>125, rue de Stalingrad 93000 Bobigny</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-15786" type="direct"></relation>
            <relation active="#struct-300210" type="direct"></relation>
            <relation active="#struct-300068" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-15786" type="direct"><org type="institution" xml:id="struct-15786" status="VALID">          <orgName>Université Paris 13</orgName>
          <orgName type="acronym">UP13</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-paris13.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300210" type="direct"><org type="institution" xml:id="struct-300210" status="VALID">          <orgName>Hôpital Avicenne</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="university">Université Paris 13</orgName>
</affiliation>
</author>
<author><name sortKey="Roux, Damien" sort="Roux, Damien" uniqKey="Roux D" first="Damien" last="Roux">Damien Roux</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-457457" status="VALID">          <orgName>Service de Réanimation Médico-Chirurgicale [Hôpital Louis Mourier]</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-344348" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-344348" type="direct"><org type="institution" xml:id="struct-344348" status="VALID">          <orgName>Hopital Louis Mourier - AP-HP [Colombes]</orgName>
          <desc>            <address>              <addrLine>178 Rue des Renouillers, 92700 Colombes</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Guerin, Laurent" sort="Guerin, Laurent" uniqKey="Guerin L" first="Laurent" last="Guérin">Laurent Guérin</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-312432" status="VALID">          <orgName>AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)</orgName>
          <desc>            <address>              <addrLine>78 Rue du Général Leclerc 94270 Le Kremlin-Bicêtre</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Mayaux, Julien" sort="Mayaux, Julien" uniqKey="Mayaux J" first="Julien" last="Mayaux">Julien Mayaux</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-244736" status="VALID">          <orgName>Service de Pneumologie et Réanimation Médicale [CHU Pitié-Salpêtrière]</orgName>
          <orgName type="acronym">Département " R3S "</orgName>
          <desc>            <address>              <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-353778" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID">          <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
          <desc>            <address>              <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Maury, Eric" sort="Maury, Eric" uniqKey="Maury E" first="Eric" last="Maury">Eric Maury</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-201319" status="VALID">          <orgName>Service de Réanimation Médicale [CHU Saint-Antoine]</orgName>
          <desc>            <address>              <addrLine>184, rue du Faubourg Saint-Antoine 75012 Paris</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-454982" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID">          <orgName>CHU Saint-Antoine [APHP]</orgName>
          <desc>            <address>              <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Ferre, Alexis" sort="Ferre, Alexis" uniqKey="Ferre A" first="Alexis" last="Ferré">Alexis Ferré</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-302301" status="VALID">          <orgName>Centre Hospitalier de Versailles</orgName>
          <orgName type="acronym">CHV</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">https://www.ch-versailles.fr</ref>
          </desc>
        </hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Georger, Jean Francois" sort="Georger, Jean Francois" uniqKey="Georger J" first="Jean-François" last="Georger">Jean-François Georger</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-408093" status="INCOMING">          <orgName>Centre Hospitalier Intercommunal de Villeneuve-Saint-Georges (CHIV)</orgName>
          <desc>            <address>              <addrLine>40, allée de la source 94195 Villeneuve Saint Georges</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Voiriot, Guillaume" sort="Voiriot, Guillaume" uniqKey="Voiriot G" first="Guillaume" last="Voiriot">Guillaume Voiriot</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-457448" status="VALID">          <orgName>Service de Réanimation médico-chirurgicale [CHU Tenon]</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-328304" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-328304" type="direct"><org type="institution" xml:id="struct-328304" status="VALID">          <orgName>CHU Tenon [APHP]</orgName>
          <desc>            <address>              <addrLine>4 Rue de la Chine, 75020 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-tenon-1</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Enouf, Vincent" sort="Enouf, Vincent" uniqKey="Enouf V" first="Vincent" last="Enouf">Vincent Enouf</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-92458" status="VALID">          <orgName>Centre National de Référence de la Grippe (France Nord) - Centre Collaborateur de l'OMS Grippe et autres virus respiratoires (CNR - CCOMS)</orgName>
          <desc>            <address>              <addrLine>Unité de Génétique moléculaire des Virus à ARN 25-28, rue du Docteur Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300027" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID">          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <date type="start">1887-06-04</date>
          <desc>            <address>              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-525918" status="OLD">          <idno type="RNSR">200818198A</idno>
          <orgName>Génétique moléculaire des virus à ARN</orgName>
          <orgName type="acronym">(U-Pasteur_ 2 / UMR_3569)</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Institut Pasteur25-28 rue du Docteur ROUX75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr/fr/sante-publique/centres-nationaux-reference/cnr/virus-infections-respiratoires-dont-grippe</ref>
          </desc>
          <listRelation>            <relation active="#struct-300027" type="direct"></relation>
            <relation name="U-Pasteur_ 2" active="#struct-300301" type="direct"></relation>
            <relation name="UMR_3569" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID">          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <date type="start">1887-06-04</date>
          <desc>            <address>              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U-Pasteur_ 2" active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD">          <idno type="ISNI">0000000121514068</idno>
          <idno type="IdRef">027542084</idno>
          <orgName>Université Paris Diderot - Paris 7</orgName>
          <orgName type="acronym">UPD7</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-paris-diderot.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR_3569" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Dessap, Armand Mekontso" sort="Dessap, Armand Mekontso" uniqKey="Dessap A" first="Armand Mekontso" last="Dessap">Armand Mekontso Dessap</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-103061" status="VALID">          <orgName>Groupe Henri Mondor-Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-300087" type="direct"></relation>
            <relation active="#struct-300088" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300087" type="direct"><org type="institution" xml:id="struct-300087" status="VALID">          <orgName>Hôpital Henri Mondor</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300088" type="direct"><org type="institution" xml:id="struct-300088" status="VALID">          <orgName>Hôpital Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="De Prost, Nicolas" sort="De Prost, Nicolas" uniqKey="De Prost N" first="Nicolas" last="De Prost">Nicolas De Prost</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-103061" status="VALID">          <orgName>Groupe Henri Mondor-Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-300087" type="direct"></relation>
            <relation active="#struct-300088" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300087" type="direct"><org type="institution" xml:id="struct-300087" status="VALID">          <orgName>Hôpital Henri Mondor</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300088" type="direct"><org type="institution" xml:id="struct-300088" status="VALID">          <orgName>Hôpital Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-02383473</idno>
<idno type="halId">hal-02383473</idno>
<idno type="halUri">https://hal.sorbonne-universite.fr/hal-02383473</idno>
<idno type="url">https://hal.sorbonne-universite.fr/hal-02383473</idno>
<idno type="doi">10.1093/cid/ciz904</idno>
<date when="2019-09-20">2019-09-20</date>
<idno type="wicri:Area/Hal/Corpus">000227</idno>
<idno type="wicri:Area/Hal/Curation">000227</idno>
<idno type="wicri:Area/Hal/Checkpoint">000008</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000008</idno>
<idno type="wicri:doubleKey">1058-4838:2019:Behillil S:oseltamivir:resistance:in</idno>
<idno type="wicri:Area/Main/Merge">000025</idno>
<idno type="wicri:Area/Main/Curation">000025</idno>
<idno type="wicri:Area/Main/Exploration">000025</idno>
<idno type="wicri:Area/France/Extraction">000002</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study</title>
<author><name sortKey="Behillil, Sylvie" sort="Behillil, Sylvie" uniqKey="Behillil S" first="Sylvie" last="Behillil">Sylvie Behillil</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-525918" status="OLD">          <idno type="RNSR">200818198A</idno>
          <orgName>Génétique moléculaire des virus à ARN</orgName>
          <orgName type="acronym">(U-Pasteur_ 2 / UMR_3569)</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Institut Pasteur25-28 rue du Docteur ROUX75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr/fr/sante-publique/centres-nationaux-reference/cnr/virus-infections-respiratoires-dont-grippe</ref>
          </desc>
          <listRelation>            <relation active="#struct-300027" type="direct"></relation>
            <relation name="U-Pasteur_ 2" active="#struct-300301" type="direct"></relation>
            <relation name="UMR_3569" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID">          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <date type="start">1887-06-04</date>
          <desc>            <address>              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U-Pasteur_ 2" active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD">          <idno type="ISNI">0000000121514068</idno>
          <idno type="IdRef">027542084</idno>
          <orgName>Université Paris Diderot - Paris 7</orgName>
          <orgName type="acronym">UPD7</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-paris-diderot.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR_3569" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="May, Faten" sort="May, Faten" uniqKey="May F" first="Faten" last="May">Faten May</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-103061" status="VALID">          <orgName>Groupe Henri Mondor-Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-300087" type="direct"></relation>
            <relation active="#struct-300088" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300087" type="direct"><org type="institution" xml:id="struct-300087" status="VALID">          <orgName>Hôpital Henri Mondor</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300088" type="direct"><org type="institution" xml:id="struct-300088" status="VALID">          <orgName>Hôpital Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Fourati, Slim" sort="Fourati, Slim" uniqKey="Fourati S" first="Slim" last="Fourati">Slim Fourati</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-103061" status="VALID">          <orgName>Groupe Henri Mondor-Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-300087" type="direct"></relation>
            <relation active="#struct-300088" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300087" type="direct"><org type="institution" xml:id="struct-300087" status="VALID">          <orgName>Hôpital Henri Mondor</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300088" type="direct"><org type="institution" xml:id="struct-300088" status="VALID">          <orgName>Hôpital Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Luyt, Charles Edouard" sort="Luyt, Charles Edouard" uniqKey="Luyt C" first="Charles-Edouard" last="Luyt">Charles-Edouard Luyt</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-353778" status="VALID">          <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
          <desc>            <address>              <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
          </desc>
        </hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Chicheportiche, Thomas" sort="Chicheportiche, Thomas" uniqKey="Chicheportiche T" first="Thomas" last="Chicheportiche">Thomas Chicheportiche</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-353778" status="VALID">          <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
          <desc>            <address>              <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
          </desc>
        </hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Sonneville, Romain" sort="Sonneville, Romain" uniqKey="Sonneville R" first="Romain" last="Sonneville">Romain Sonneville</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2607" status="VALID">          <orgName>CIC - CHU Bichat</orgName>
          <desc>            <address>              <addrLine>Gh Xavier Bichat - Claude Bernard PARIS VII 46, Rue Henri Huchard 75018 PARIS</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="CIC7" active="#struct-303623" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="CIC7" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Tandjaoui Lambiotte, Yacine" sort="Tandjaoui Lambiotte, Yacine" uniqKey="Tandjaoui Lambiotte Y" first="Yacine" last="Tandjaoui-Lambiotte">Yacine Tandjaoui-Lambiotte</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-85018" status="OLD">          <orgName>Service de Réanimation Médico-Chirurgicale [Avicenne]</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>125, rue de Stalingrad 93000 Bobigny</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-15786" type="direct"></relation>
            <relation active="#struct-300210" type="direct"></relation>
            <relation active="#struct-300068" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-15786" type="direct"><org type="institution" xml:id="struct-15786" status="VALID">          <orgName>Université Paris 13</orgName>
          <orgName type="acronym">UP13</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-paris13.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300210" type="direct"><org type="institution" xml:id="struct-300210" status="VALID">          <orgName>Hôpital Avicenne</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="university">Université Paris 13</orgName>
</affiliation>
</author>
<author><name sortKey="Roux, Damien" sort="Roux, Damien" uniqKey="Roux D" first="Damien" last="Roux">Damien Roux</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-457457" status="VALID">          <orgName>Service de Réanimation Médico-Chirurgicale [Hôpital Louis Mourier]</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-344348" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-344348" type="direct"><org type="institution" xml:id="struct-344348" status="VALID">          <orgName>Hopital Louis Mourier - AP-HP [Colombes]</orgName>
          <desc>            <address>              <addrLine>178 Rue des Renouillers, 92700 Colombes</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Guerin, Laurent" sort="Guerin, Laurent" uniqKey="Guerin L" first="Laurent" last="Guérin">Laurent Guérin</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-312432" status="VALID">          <orgName>AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)</orgName>
          <desc>            <address>              <addrLine>78 Rue du Général Leclerc 94270 Le Kremlin-Bicêtre</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Mayaux, Julien" sort="Mayaux, Julien" uniqKey="Mayaux J" first="Julien" last="Mayaux">Julien Mayaux</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-244736" status="VALID">          <orgName>Service de Pneumologie et Réanimation Médicale [CHU Pitié-Salpêtrière]</orgName>
          <orgName type="acronym">Département " R3S "</orgName>
          <desc>            <address>              <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-353778" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID">          <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
          <desc>            <address>              <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Maury, Eric" sort="Maury, Eric" uniqKey="Maury E" first="Eric" last="Maury">Eric Maury</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-201319" status="VALID">          <orgName>Service de Réanimation Médicale [CHU Saint-Antoine]</orgName>
          <desc>            <address>              <addrLine>184, rue du Faubourg Saint-Antoine 75012 Paris</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-454982" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID">          <orgName>CHU Saint-Antoine [APHP]</orgName>
          <desc>            <address>              <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Ferre, Alexis" sort="Ferre, Alexis" uniqKey="Ferre A" first="Alexis" last="Ferré">Alexis Ferré</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-302301" status="VALID">          <orgName>Centre Hospitalier de Versailles</orgName>
          <orgName type="acronym">CHV</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">https://www.ch-versailles.fr</ref>
          </desc>
        </hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Georger, Jean Francois" sort="Georger, Jean Francois" uniqKey="Georger J" first="Jean-François" last="Georger">Jean-François Georger</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-408093" status="INCOMING">          <orgName>Centre Hospitalier Intercommunal de Villeneuve-Saint-Georges (CHIV)</orgName>
          <desc>            <address>              <addrLine>40, allée de la source 94195 Villeneuve Saint Georges</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Voiriot, Guillaume" sort="Voiriot, Guillaume" uniqKey="Voiriot G" first="Guillaume" last="Voiriot">Guillaume Voiriot</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-457448" status="VALID">          <orgName>Service de Réanimation médico-chirurgicale [CHU Tenon]</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-328304" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-328304" type="direct"><org type="institution" xml:id="struct-328304" status="VALID">          <orgName>CHU Tenon [APHP]</orgName>
          <desc>            <address>              <addrLine>4 Rue de la Chine, 75020 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-tenon-1</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Enouf, Vincent" sort="Enouf, Vincent" uniqKey="Enouf V" first="Vincent" last="Enouf">Vincent Enouf</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-92458" status="VALID">          <orgName>Centre National de Référence de la Grippe (France Nord) - Centre Collaborateur de l'OMS Grippe et autres virus respiratoires (CNR - CCOMS)</orgName>
          <desc>            <address>              <addrLine>Unité de Génétique moléculaire des Virus à ARN 25-28, rue du Docteur Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300027" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID">          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <date type="start">1887-06-04</date>
          <desc>            <address>              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-525918" status="OLD">          <idno type="RNSR">200818198A</idno>
          <orgName>Génétique moléculaire des virus à ARN</orgName>
          <orgName type="acronym">(U-Pasteur_ 2 / UMR_3569)</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Institut Pasteur25-28 rue du Docteur ROUX75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr/fr/sante-publique/centres-nationaux-reference/cnr/virus-infections-respiratoires-dont-grippe</ref>
          </desc>
          <listRelation>            <relation active="#struct-300027" type="direct"></relation>
            <relation name="U-Pasteur_ 2" active="#struct-300301" type="direct"></relation>
            <relation name="UMR_3569" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID">          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <date type="start">1887-06-04</date>
          <desc>            <address>              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U-Pasteur_ 2" active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD">          <idno type="ISNI">0000000121514068</idno>
          <idno type="IdRef">027542084</idno>
          <orgName>Université Paris Diderot - Paris 7</orgName>
          <orgName type="acronym">UPD7</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-paris-diderot.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR_3569" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Dessap, Armand Mekontso" sort="Dessap, Armand Mekontso" uniqKey="Dessap A" first="Armand Mekontso" last="Dessap">Armand Mekontso Dessap</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-103061" status="VALID">          <orgName>Groupe Henri Mondor-Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-300087" type="direct"></relation>
            <relation active="#struct-300088" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300087" type="direct"><org type="institution" xml:id="struct-300087" status="VALID">          <orgName>Hôpital Henri Mondor</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300088" type="direct"><org type="institution" xml:id="struct-300088" status="VALID">          <orgName>Hôpital Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="De Prost, Nicolas" sort="De Prost, Nicolas" uniqKey="De Prost N" first="Nicolas" last="De Prost">Nicolas De Prost</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-103061" status="VALID">          <orgName>Groupe Henri Mondor-Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-300087" type="direct"></relation>
            <relation active="#struct-300088" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300087" type="direct"><org type="institution" xml:id="struct-300087" status="VALID">          <orgName>Hôpital Henri Mondor</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300088" type="direct"><org type="institution" xml:id="struct-300088" status="VALID">          <orgName>Hôpital Albert Chenevier</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1093/cid/ciz904</idno>
<series><title level="j">Clinical Infectious Diseases</title>
<idno type="ISSN">1058-4838</idno>
<imprint><date type="datePub">2019-09-20</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Adult</term>
<term>H1N1 Subtype</term>
<term>Influenza A Virus</term>
<term>Oseltamivir</term>
<term>Pneumonia</term>
<term>Respiratory Distress Syndrome</term>
<term>Viral</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>In a multicenter cohort study including 22 oseltamivir-treated patients with influenza A(H1N1)pdm09 acute respiratory distress syndrome, prevalence of the H275Y substitution in the neuraminidase, responsible for highly reduced sensitivity to oseltamivir, was 23%. Patients infected with the H275Y mutant virus had higher day-28 mortality than others (80% vs 12%; p=0.011).</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
</settlement>
<orgName><li>Université Paris 13</li>
</orgName>
</list>
<tree><country name="France"><noRegion><name sortKey="Behillil, Sylvie" sort="Behillil, Sylvie" uniqKey="Behillil S" first="Sylvie" last="Behillil">Sylvie Behillil</name>
</noRegion>
<name sortKey="Chicheportiche, Thomas" sort="Chicheportiche, Thomas" uniqKey="Chicheportiche T" first="Thomas" last="Chicheportiche">Thomas Chicheportiche</name>
<name sortKey="De Prost, Nicolas" sort="De Prost, Nicolas" uniqKey="De Prost N" first="Nicolas" last="De Prost">Nicolas De Prost</name>
<name sortKey="Dessap, Armand Mekontso" sort="Dessap, Armand Mekontso" uniqKey="Dessap A" first="Armand Mekontso" last="Dessap">Armand Mekontso Dessap</name>
<name sortKey="Enouf, Vincent" sort="Enouf, Vincent" uniqKey="Enouf V" first="Vincent" last="Enouf">Vincent Enouf</name>
<name sortKey="Ferre, Alexis" sort="Ferre, Alexis" uniqKey="Ferre A" first="Alexis" last="Ferré">Alexis Ferré</name>
<name sortKey="Fourati, Slim" sort="Fourati, Slim" uniqKey="Fourati S" first="Slim" last="Fourati">Slim Fourati</name>
<name sortKey="Georger, Jean Francois" sort="Georger, Jean Francois" uniqKey="Georger J" first="Jean-François" last="Georger">Jean-François Georger</name>
<name sortKey="Guerin, Laurent" sort="Guerin, Laurent" uniqKey="Guerin L" first="Laurent" last="Guérin">Laurent Guérin</name>
<name sortKey="Luyt, Charles Edouard" sort="Luyt, Charles Edouard" uniqKey="Luyt C" first="Charles-Edouard" last="Luyt">Charles-Edouard Luyt</name>
<name sortKey="Maury, Eric" sort="Maury, Eric" uniqKey="Maury E" first="Eric" last="Maury">Eric Maury</name>
<name sortKey="May, Faten" sort="May, Faten" uniqKey="May F" first="Faten" last="May">Faten May</name>
<name sortKey="Mayaux, Julien" sort="Mayaux, Julien" uniqKey="Mayaux J" first="Julien" last="Mayaux">Julien Mayaux</name>
<name sortKey="Roux, Damien" sort="Roux, Damien" uniqKey="Roux D" first="Damien" last="Roux">Damien Roux</name>
<name sortKey="Sonneville, Romain" sort="Sonneville, Romain" uniqKey="Sonneville R" first="Romain" last="Sonneville">Romain Sonneville</name>
<name sortKey="Tandjaoui Lambiotte, Yacine" sort="Tandjaoui Lambiotte, Yacine" uniqKey="Tandjaoui Lambiotte Y" first="Yacine" last="Tandjaoui-Lambiotte">Yacine Tandjaoui-Lambiotte</name>
<name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
<name sortKey="Voiriot, Guillaume" sort="Voiriot, Guillaume" uniqKey="Voiriot G" first="Guillaume" last="Voiriot">Guillaume Voiriot</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000002 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000002 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Hal:hal-02383473
   |texte=   Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration H2N2

Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study

Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri